|
KMID : 0376219750120030663
|
|
Chonnam Medical Journal
1975 Volume.12 No. 3 p.663 ~ p.669
|
|
|
A study on the non-adrenergic and non-cholinergic innervation to the detrusor muscle of the urinary bladder in the rabbit
|
|
|
|
|
Abstract
|
|
|
It has been suggested that some organs under the adrenergic and cholinergic innervation are also innervated by non-adrenergic and non-cholinergic fibers. However, the nature of these fibers which are neither adrenergic nor cholinergic is not extensively studied.
Recently, evidence has been indicated that a purine nucleotide, probably adenosine triphophate (ATP), may be the transmitter substance released from the non-adrenergic, non-cholinergic fibers. Consequently these fibers have been tentatively termed "purinergic".
In this study utilizing the detrusor muscle of the urinary bladder of the rabbit responses of the muscle to the transmural and perivascular stimulation; and response of the muscle to ATP were studied. In addition the influence of some autonomic drugs on the response of the muscle to the transmural and perivascular stimulations were also investigated. The results obtained were as follows.
1. Transmural and perivascular stimulation provoked marked contraction of the detrusor muscle.
2. The responses of the detrusor muscle to the transmural and perivascular stimulation were not affected in the presence of either regitine, propranolol or atropine.
3. Adenosine triphosphate produced marked contraction of- the detrusor;inuscle.
4. The time course of contraction response to the transmural and perivascular stimulations was similar to that of adenosine triphosphate.
5. These results summarized above suggdst that the detrusor muscle of the urinary bladder is also innervated by non-adrenergic and non-cholinergic excitatory fibers, and, that the nature of the fibers seems to be purinergic.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|